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Adaptive mutation
The turning point in the research on the origin of mutations came when researchers found out that during non-lethal and non-mutagenic selective pressure, non-growing or slowly growing bacterial cells experience a specific mutation, named adaptive mutation, that relieves the selective pressure.
The origin of the adaptive mutation is, according to many experimental results, in a tight connection with the nature of the cell's dynamical organization. Namely, molecular events that mark the
final step in the adaptive mutation process, for example the
insertion of the mobile element into the appropriate genomic
region, is only one of many molecular motions and transformations
that is going on in that particular moment. To understand how such molecular events are organized inside the cell and how they are directed, if they are
directed at all, a new scientific
approach named information bioelectromagnetics, is needed.
Results of our research are quite
intriguing and they support a notion that the nature of the
cell's organisation is not conformant to modern molecular -
reductionist conceptions. Namely, we found out that
adaptive, and not growth-dependent, mutations are affected by magnesium present in the environment. Magnesium affects the process of adaptive mutation classically as an ion or as an information imprint which is non-chemically transmitted information imprint of magnesium to water by a combination of high voltage electric and magnetic fields.
Our references:
Jerman I., R. Ružič, R. Krašovec, M. Škarja, and L. Mogilnicki. 2005. Electrical transfer of molecule information into water, its storage and bioeffects on plants and bacteria. Electromagnetic Biology and Medicine, 24: 341-353.
Krašovec R., Jerman I., Škarja M. 2005. Electromagnetic information imprinted into medium act as environmental signal for bacteria Escherichia coli. In: Coherence and Electromagnetic fields in Biological Systems, In: Coherence and Electromagnetic fields in Biological Systems, July 1-4, (ed.) Pokorny J. Czech Republic. Institute of Radio Engineering and Electronics, Prague, pp. 146-148.
Krašovec R. 2005. Adaptive mutation in bacteria Escherichia coli as biological function. Doctoral dissertation,
University of Ljubljana , Biotechnical Faculty, Department of Biology,
190 p.
Krašovec R. & Jerman I. Bacterial multicellularity
as a possible source of antibiotic resistance. Medical Hypotheses;
60(4): 484-488, 2003.
Krašovec R. & Jerman I. Adaptive
mutation: shall we survive bacterial genetic skills? Acta
Biologica Slovenica; 45(2): 15-24, 2002.
Krašovec R. & Jerman I. Is
a sort of intelligence at work in bacteria?, Proceedings
of the 5th International Multi-Conference Information Society
- Cognitive Sciences, (ed.) Repovš
G., Gams M. & Detela
A., Ljubljana, 58-60, 2002.
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